Appendix 1. Overview of the running projects using NET-QUBIC data

PhD projects

1. The course of health related quality of life in relation to survival (Amsterdam UMC, location VUmc, project leader IM Verdonck-de Leeuw)
2. Depression in head and neck cancer patients and the relation with survival (Amsterdam UMC, location VUmc, project leader IM Verdonck-de Leeuw),
3. Treatment optimization in elderly head and neck cancer patients (UMCG, project leader JA Langendijk),
4. Development and validation of predictive models for objectively and subjectively measured salivary, mastication, and swallowing function in relation to quality of life among patients treated for head and neck cancer (UMCU, project leader CHJ Terhaard),
5. Fear of recurrence in head and neck cancer patients (Radboudumc, project leaders RP Takes and JB Prins).
6. Sleep disturbances in newly diagnosed head and neck cancer patients (Vrije Universiteit Amsterdam, project leader IM Verdonck-de Leeuw)
7. Head and neck cancer long-term survivorship: Late effects, supportive care needs and healthcare utilization of survivors and their caregivers (Amsterdam UMC, location VUmc project leader F Jansen)

Single studies

1. Cognitive function in relation to speech problems in head and neck cancer prior to treatment (Radboudumc, project leader V Piai)
2. Physical activity and fitness in patients with Head and Neck Cancer (Amsterdam UMC, location VUmc, project leader LM Buffart)
3. Fear of cancer recurrence in head and neck cancer patients: A cross-sectional study of prevalence and associated demographic, clinical, psychological and behavioral characteristics (Radboudumc, project leader JB Prins)
4. Liquid biopsy analysis for early diagnosis of recurrent/metastatic head and neck cancer (Amsterdam UMC, project leader RH Brakenhoff)
5. Waiting times for diagnosis and treatment of head and neck cancer in relation to distress, anxiety and quality of life (Radboudumc, project leader RP Takes)
6. Sexual problems among head and neck cancer patients at time of diagnosis and in the first six months after treatment: who is at risk? (Amsterdam UMC, project leader IM Verdonck-de Leeuw)
7. Neurocognitive functioning in head and neck cancer: baseline prevalence, possible causes, and the impact of treatment (Radboudumc, project leader V Piai)
8. A prospective longitudinal study of fear of cancer recurrence in newly-diagnosed head and neck cancer patients: course, trajectory and associated psychological variables (Radboudumc, project leader JB Prins)
9. Supportive care needs among head and neck cancer patients from diagnosis up to 6 months follow-up: a longitudinal cohort study (Amsterdam UMC, location VUmc project leader F Jansen)
10. Psychosocial functioning and supportive care needs of caregivers of patients with head and neck cancer (ErasmusMC, project leader A Hoesseini)
11. Development and external validation of NTCP-models for patient-rated hearing loss in patients treated with radiotherapy for head and neck cancer (UMCG, project leader JA Langendijk)
12. External validation of comprehensive individualized toxicity risk (CITOR) profiles in a multicenter setting in the Netherlands (UMCG, project leader JA Langendijk)
13. Neurocognitive dysfunction after radiotherapy for head and neck cancer (UMCG, project leader JA Langendijk)
14. Correlation of skeletal muscle mass and muscle strength in head and neck cancer patients (UMCU, project leader R de Bree)
15. The oral microbiome in head and neck cancer patients; an explorative pilot study into the composition and dynamics of the oral microbiome at diagnosis and 6 months post-therapy and relationships with fatigue, anxiety and depression. (ACTA, project leader J Raber-Durlacher)
16. Are changes in dietary intake and physical activity (synergistically) associated with changes in nutritional status and quality of life in the period between head and neck cancer diagnosis and 6 months follow up? (Hanzehogeschool Groningen, project leader H Jager-Wittenaar)
17. Dental rehabilitation in head and neck cancer patients with loss of oral hard tissue and the relation with quality of life (AmsterdamUMC, project leader F Leusink)
18. Rare somatic mutations as risk biomarkers for cancer (AmsterdamUMC, project leader J Poell)
19. Quality of life of patient treated for oral cavity squamous cell carcinoma: conventional versus ultrasound guided surgery (UMCU, project leader R Noorlag)
20. A Comparison of Quality of Life Among Head and Neck Cancer Patients across Three Time Points (Mainz University (Germany), project leader K Taylor)
21. Identification and prediction of trajectories of fear of cancer recurrence in the first two years after a head and neck cancer diagnosis. (Radboudumc, project leader J Custers)
22. Fatigue and sleep disturbances in informal caregivers of patients with head and neck cancer: a two year longitudinal cohort study (Radboudumc, project leader L Kwakkenbos)
23. The effect of treatment delay on health related quality of life, psychological functioning, supportive care needs and survival in head and neck cancer patients (UMCU, project leader R de Bree)
24. Dynamic prediction of survival with repeatedly measured covariates (AmsterdamUMC, project leader BI Lissenberg-Witte)
25. RADiotherapy for head and neck cancer and the influence on TASTE (RAD-TASTE) (UMCU. Project leader M de Ridder)
26. The impact of swallowing problems, oral function and malnutrition on the course of social eating in patients with head and neck cancer treated with (chemo)radiotherapy: a longitudinal study (University of Milan (Italy), project leader A Ninfa)